Skin and Pigmentary Changes in Vogt–Koyanagi–Harada Syndrome
Dermatological changes are a distinctive feature of Vogt–Koyanagi–Harada syndrome, typically emerging during the later stages of the disease. These changes result from immune-mediated destruction of melanocytes in the skin and hair follicles.
Vitiligo, characterized by patchy loss of skin pigmentation, is one of the most recognizable signs. Poliosis, or whitening of hair and eyelashes, may also occur. Alopecia can develop in some individuals, reflecting broader melanocyte involvement.
While these changes do not directly threaten vision, they can have a significant psychological impact. Awareness and supportive care are important components of comprehensive disease management.
Skin manifestations serve as important diagnostic clues, reinforcing the systemic nature of VKH syndrome. Their presence often indicates a chronic disease phase requiring long-term monitoring.